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Everyday Health: Can diabetes medications help obese people who aren’t diabetic lose weight as well?

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There are two classes of diabetes medicines that help in substantial weight loss. The morbidly obese may choose to use these drugs before thinking of bariatric surgeries. SGLT-2 inhibitors, which act by eliminating glucose in the urine and preventing its re-absorption in the kidneys.

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Women are more vulnerable than men to gonorrhea due to rising antibiotic resistance.

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Don’t engage in sexual activity. It is “the only way to completely avoid STIs,” according to public health organizations. Avoid engaging in any oral, anal, or vaginal sex.

It is a sobering piece of wisdom. However, it also makes perfect sense when you look at the most recent data on the spread of antimicrobial resistance (AMR) and bacterial STIs, such as gonorrhea, from the European Centre for Disease Prevention and Control (ECDC).

Antibiotics including azithromycin, ceftriaxone, and cefixime are frequently used in medicine to treat gonorrhea, but their efficacy is declining. And that might be a factor in the rise in gonorrhea infections and STI cases in general throughout Europe, if not the world.

In a study released on June 10, 2024, the ECDC stated that there were 70,881 confirmed cases of gonorrhea in 28 EU/EEA (European Union/European Economic Area) nations in 2022, a 48% increase from the previous year.

AMR is one reason why antibiotics across the board — whether it’s for STIs or an earache — are failing public health efforts. Either we use them too much, or we don’t bother to take all the pills, with the result that bacteria are able to build up a resistance to many of our “go-to” drugs of the past 100 years.

Gonorrhea: What is it?
The Neisseria gonorrhoea bacteria is the cause of gonorrhea. It may impact the esophagus, rectum, or genitalia. Infections are common in young persons (ages 15 to 24).

Women are more likely than males to get an infection since diagnosis is more difficult for them. Women also frequently don’t have symptoms, and when they do, they are typically minor and can be confused for another vaginal or bladder infection. particularly expectant mothers, who may transmit STI infections to their fetus. Undiagnosed sexually transmitted infections can cause pregnancy problems in women or cause infertility.

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However, men do experience symptoms, such as painful or enlarged testicles, a burning feeling when peeing, and a discharge that can be white, yellow, or green.

However, this is less common in women than it is in them. Teodora Elvira Wi, who oversees the global HIV, hepatitis, and STI programs at the World Health Organization in Geneva, stated that women must be given priority because they are asymptomatic.

“We need opportunities for women to be screened for STIs, and especially people at higher risk, people who have multiple partners and sexually active adolescents,” stated Wi.

Concerning’ antimicrobial resistance to popular medications for gonorrhea
In the ECDC paper, 4,396 gonorrhea samples (also known as “isolates”) from 23 different nations were analyzed. These samples were taken in 2022.

They discovered that “isolates resistant to azithromycin increased significantly to 25.6%, compared to 14.2% in 2021.”

Since azithromycin and ceftriaxone are frequently used together, the ECDC deemed this result to be “particularly concerning.”

Ciprofloxacin resistance rose as well, though not as dramatically: in 2022, 65.9% of isolates showed resistance, up from 62.8% in 2021.

Cefixime resistance remained “low at 0.3%.”

All things considered, the World Health Organization’s data from other regions—Africa and Asia, for example—reflects the ECDC figures.

According to Wi, 73 countries worldwide have reported antimicrobial resistance data in gonorrhea. “Antimicrobial resistance is not the only cause [there], but in countries where antimicrobial resistance is even higher than in Europe, it is contributing to the increase in bacterial STIs,” Wi added.

Pharyngeal (throat) gonorrhea was on the rise in 2022, according to ECDC data, although genital and anorectal gonorrhea cases stayed steady.

How to reduce STI transmission
According to WHO data from 2020, 374 million new cases of syphilis, gonorrhea, chlamydia, and trichomoniasis among individuals aged 15 to 49 occur worldwide each year. The increasing incidence of STI cases was attributed by the WHO to the following factors:

An increase in risky sexual conduct, such as the usage of fewer condoms and a rise in the number of casual and committed relationships

Socioeconomic factors and asymptomatic infections; biological considerations

Due to underfunding of services, there is a paucity of STI services, poor access to STI services, and a shortage of diagnostic test instruments.

Stigma: As a result of stigma, STI services and research are underfunded, and patients are less likely to seek treatment.

In public health initiatives to limit STIs, addressing and/or reversing these variables would be a smart place to start.

Wi advised against quitting entirely, saying that having sex should be accompanied by education. “Have sex, have pleasure in sex, make it a voluntary thing, do it for your sexual well-being and protect yourself the way you protect yourself from other infections,” she stated.

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Kidney cancer: 7 lifestyle choices that harm your kidneys and increase your risk of developing the disease

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Without any obvious symptoms, kidney cancer can begin to grow silently in the cells of your vital organ. Age is a risk factor for this malignancy, and lifestyle choices have a significant impact on its development. In 2023, there were about 4,600 new cases of kidney cancer, with an average age of 65 at diagnosis.

The risk of kidney cancer is twice as high for smokers as it is for non-smokers. As you age, you are heavily at risk for kidney cancer even if you do not smoke or drink and you do not lead an active lifestyle or eat poorly. Renal cell carcinoma (RCC) is the most prevalent kind of kidney cancer, making up roughly 90% of cases.

Without any obvious symptoms, kidney cancer can begin to grow silently in the cells of your vital organ. Age is a risk factor for this malignancy, and lifestyle choices have a significant impact on its development. In 2023, there were about 4,600 new cases of kidney cancer, with an average age of 65 at diagnosis.
The kidneys are organs that function to control blood pressure, preserve electrolyte balance, and filter waste and extra fluid from the blood. However, a number of factors, such as medical disorders and lifestyle decisions, might impair kidney health. Kidney cancer is one such issue, which is typified by the aberrant proliferation of kidney cells. Kidney cancer can progress quickly if treatment is not received, offering major health hazards, even though it may not necessarily show symptoms in its early stages. Dr. Raghunath S.K., Senior Consultant and Director of Uro-oncology and Robotic Surgery, HCG Cancer Centre, KR Road, Bangalore, adds that fortunately, there are actions you may do to enhance kidney health and lower the chance of kidney cancer and other related issues.

Without any obvious symptoms, kidney cancer can begin to grow silently in the cells of your vital organ. Age is a risk factor for this malignancy, and lifestyle choices have a significant impact on its development. In 2023, there were about 4,600 new cases of kidney cancer, with an average age of 65 at diagnosis.

“Smoking, obesity, and genetic predisposition are among the factors that are frequently associated with kidney cancer. Urine with blood in it, back discomfort, exhaustion, and weight loss are some of the symptoms. Imaging examinations are part of the diagnosis. According to the patient’s condition and the cancer’s stage, treatment options include immunotherapy, surgery, targeted therapy, and clinical trial participation, says Dr. Raghunath.

A better prognosis requires early detection. It is necessary to take some preventative steps in order to reduce the risk of kidney cancer.

Lifestyle errors to prevent kidney cancer
In order to protect your kidneys from cancer, you should avoid the following lifestyle faults, as advised by Dr. Raghunath SK:

1. Not eating a balanced diet: Make fruits, vegetables, and whole grains your top priorities and cut back on processed meats, sugar-filled drinks, and harmful fats. These foods are rich in nutrients and include vital vitamins, minerals, and antioxidants that promote healthy kidney function and lower the risk of kidney cancer.

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2. Excess weight: Make conscious eating choices and frequent exercise your way to a healthy body weight. Being overweight raises the risk of cancer and renal disease as well as puts strain on the kidneys. To promote weight management and general health, concentrate on eating a range of nutrient-rich meals in sensible portions.

3. Not drinking enough water: Drinking enough water is crucial for healthy kidney function as well as the body’s removal of waste and pollutants. To maintain optimal kidney health, strive for at least 8 glasses (or 2 litres) of water throughout the day. Keep an eye on the colour of your urine; pale yellow pee denotes sufficient hydration.

4. Alcohol and smoking: Excessive alcohol intake and smoking are important risk factors for kidney cancer. You can lower your chance of developing cancer and preserve your kidneys by giving up smoking and drinking in moderation. If you need help reducing or quitting drinking or smoking, get in touch with support groups or medical specialists.

5. Not controlling blood pressure: High blood pressure raises the risk of renal disease and cancer by causing gradual damage to the kidneys. Regularly check your blood pressure and make lifestyle changes (balanced diet, regular exercise, stress reduction, medication if needed) to maintain it within a healthy range. Seek advice from your healthcare provider for specific recommendations.

6. Elevated blood sugar: Diabetics are more likely to develop renal problems and cancer. Keep your blood sugar under strict control with a healthy diet, regular exercise, medication, and monitoring. To reduce the risk of kidney issues, keep an eye on your carbohydrate intake, get regular exercise, and follow your diabetes treatment plan.

7. Abusing a lot of painkillers: Overuse of several over-the-counter painkillers can be harmful to the kidneys. Nonsteroidal anti-inflammatory medications (NSAIDs) have to be taken with caution and under a doctor’s supervision. Think about complementary and alternative methods of treating pain, like heat therapy, acupuncture, or physical therapy. Never exceed the stated dosage limits, and do not use NSAIDs for an extended period of time without a prescription.

By implementing easy-to-use yet powerful techniques into regular routines, individuals can take proactive steps towards protecting their kidneys and maintaining optimal health.

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Sodium consumption and eczema risk: A study suggests that eating too much salt may increase the likelihood of skin inflammation.

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A recent study discovered that high sodium intake, which is typically obtained via salt, may raise the chance of developing eczema, an inflammatory skin condition characterised by dry, itchy spots.

Studies in the past have discovered a connection between skin sodium levels and autoimmune diseases as well as chronic inflammatory disorders like eczema. Additionally, research has demonstrated that eating fast food, which is known to have high levels of sodium in the diet, raises a teen’s risk of developing eczema, particularly severe cases.

According to a recent study, eating merely one gramme more of sodium than is recommended daily can raise the risk of eczema flare-ups by 22%. A Big Mac, a hamburger offered by the global fast food company McDonald’s, or half a teaspoon of table salt both contain approximately one gramme of sodium.

The National Health Service of the United Kingdom recommends 2.3 grammes of sodium per day, although the World Health Organisation advises consuming fewer than two grammes.

The chronic skin ailment has become more widespread in recent years, especially in industrialised countries, according to study experts from the University of California San Francisco (UCSF), US. This suggests that environmental and lifestyle variables including diet had a role to play.

Thus, they suggested that cutting back on sodium consumption would be a simple strategy for eczema sufferers to control their condition. The results have been published in the Dermatology section of The Journal of the American Medical Association (JAMA).

According to UCSF associate professor of dermatology Katrina Abuabara, the study’s corresponding author, “Eczema flares can be difficult for patients to cope with, especially when they are unable to anticipate them and don’t have recommendations on what they can do to avoid them.”

The researchers collected urine samples and computerised medical information from over two lakh individuals between the ages of thirty and seventy-nine from the UK Biobank for their study.

The researchers determined each participant’s sodium intake by analysing the urine samples. They were able to determine the participant’s diagnosis of atopic dermatitis, also known as eczema, and the extent of the condition from the medical data.

The researchers discovered that eating one gramme of salt above the suggested intake increased the risk of developing the skin condition by 22 per cent.

Future research could look at restricting sodium in daily diet as an intervention for eczema, they added.

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