According to research, women are more prone to acquire cancer in both breasts

Women who have breast cancer in one breast may be more likely to develop the disease in the other, according to a new study.

Women who have cancer in one breast may be more likely to develop cancer in the opposite breast, a study suggests. Findings will help personalise approaches to breast cancer screening and risk factors, according to the study’s authors. Researchers were led by the Mayo Clinic Comprehensive Cancer Center in the US.

Patients who carry a gene mutation associated with increased risk of developing cancer in both breasts have at least a twofold increased risk, according to a study by researchers at the University of Glasgow and the Scottish Breast Research Institute (BRCR) published in The Lancet on Thursday.

Patients who carry germline ATM mutations have a significantly elevated risk of developing breast cancer, according to a study published in the Journal of Clinical Oncology. The risk is highest among those with estrogen receptor-negative disease, rather than those with hormone-receptor-positive disease.

The CARRIERS Study is one of the largest studies to provide estimates of contralateral breast cancer risk by age at diagnosis, menopausal status and race/ethnicity in germline mutation carriers.

Most patients with breast cancer who carry germline mutations assume they are at high risk of developing cancer in the opposite breast. Risk of contralateral breast cancer in carriers of a germline mutation in ATM, CHEK2 or PALB2 had not been previously established.

Premenopausal women who carry germline mutations generally have a higher risk of contralateral breast cancer. Black women and non-Hispanic white women have similarly elevated risk, researchers found. Risk management strategies should be similar to those for post-menopausal women, they say.

“Many women will undergo a bilateral mastectomy to reduce the possibility of a second breast cancer,” she says.

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